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. 2022 Jul 1;298(8):102224. doi: 10.1016/j.jbc.2022.102224

Figure 2.

Figure 2

Structure of the U2AF2 UHM bound to SF3B1 ULM5 and comparison with related complexes.A, views of the two U2AF2 UHM–SF3B1 ULM5 complexes (Complex A and Complex B) in the crystallographic asymmetric unit. The SF3B1 R337 and U2AF2 R457 side chains of complex B have two alternative conformations. B, RBM39 UHM–SF3B1 ULM5 (Protein Data Bank ID 4OZ1) or C, U2AF2 UHM–SF1 (Protein Data Bank ID 4FXW) complex viewed in a similar orientation. The UHM is colored cyan; the ULM ligand is yellow with italicized residue labels; key acidic UHM residues are red; residues in the UHM RXF motif are blue; and disordered residues are labeled in parentheses. The crystallographic data and refinement statistics are given in Table S2. Crystal packing and electron density maps are shown in Fig. S2.