Table 2:

Clinical features of histiocytoses with single organ involvement that are often associated with difficult or late diagnosis of histiocytosis

	Age	Histiocytosis group
Recurrent normolipaemic xanthelasma	Adult	ECD
Exophthalmos	Any age	L and R
Diabetes insipidus	Any age	L
Cerebellar syndrome	Any age	L
Pachymeningitis	Any age	R
Testis involvement	Adult	ECD and R
Painful legs	Adult	ECD
Vertebra plana	Child more often than adult	LCH
Recurrent dental losses with cysts	Any age	LCH
Recurrent pneumothorax	Adolescent and young adult	LCH
Interstitial lung disease	Adult	ECD and R
Obstructive renal failure	Adult	ECD and R

ECD=Erdheim-Chester disease. LCH=Langerhans cell histiocytosis.