Table 2. Baseline Patient and Graft Characteristics Among Patients in the Primary Analysis.
| No. (%) | ||
|---|---|---|
| Ticagrelor DAPT (n = 435) | Aspirin (n = 436) | |
| Patientsa | ||
| Age, median (IQR), y | 67 (60-72) | 66 (61-73) |
| >65 y | 249 (57.2) | 241 (55.3) |
| Sex | ||
| Women | 65 (14.9) | 63 (14.5) |
| Men | 370 (85.1) | 373 (85.5) |
| Medical history | ||
| Hypertensionb | 294 (67.6) | 294 (67.4) |
| Dyslipidemiac | 275 (63.2) | 266 (61.0) |
| ACS at presentationd | 195 (44.8) | 189 (43.3) |
| Diabetes | 143 (32.9) | 143 (32.8) |
| Smokinge | 114 (26.2) | 112 (25.7) |
| Previous myocardial infarction | 92 (21.2) | 91 (20.9) |
| Previous PCI | 50 (11.5) | 65 (14.9) |
| Chronic kidney diseasef | 28 (6.4) | 24 (5.5) |
| LVEF, median (IQR), %g | 58 (51-64) | 60 (51-65) |
| Use of cardiopulmonary bypass | 297 (68.3) | 301 (69.0) |
| Endoscopic saphenous vein graft harvestingh | 19/415 (4.6) | 25/410 (6.1) |
| Sequential saphenous vein grafts | 320 (73.6) | 327 (75.0) |
| Grafts | ||
| No. | 981 | 996 |
| Graft type | ||
| Saphenous vein grafts | 527 (53.7) | 537(53.9) |
| Arterial grafts | 454 (46.3) | 459 (46.1) |
| Graft target | ||
| LAD | 407 (41.5) | 403 (40.5) |
| Saphenous vein grafts | 15 (3.7) | 16 (4.0) |
| Arterial grafts | 392 (96.3) | 387 (96.0) |
| Non-LAD | 574 (58.5) | 593 (59.5) |
| Saphenous vein grafts | 512 (89.2) | 521 (87.9) |
| Arterial grafts | 62 (10.8) | 72 (12.1) |
Abbreviations: ACS, acute coronary syndrome; DAPT, dual antiplatelet therapy; LAD, left anterior descending artery; LVEF, left ventricular ejection fraction; PCI, percutaneous coronary intervention.
Includes patients from the TAP-CABG,8 DACAB,9 and POPular CABG10 trials. See the Methods section for the full names of the studies. Definitions and time points of measurement varied by trial.
History of hypertension or systolic blood pressure of at least 140 mm Hg and diastolic blood pressure of at least 90 mm Hg.
Baseline low-density lipoprotein cholesterol of at least 69.5 mg/dL (≥1.8 mmol/L).
ST-elevated myocardial infarction, non–ST-segment elevation ACS, or unstable angina.
Current and former smoking and includes vaping and use of other tobacco products.
Glomerular filtration rate less than 60 mL/min/m2 calculated by the Chronic Kidney Disease Epidemiology Collaboration formula.
The most recent measurement before surgery and varied by trial.
Changes in denominators indicate missing data.