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. 2022 Aug 10;12(8):210375. doi: 10.1098/rsob.210375

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© 2022 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 4. — Validation of the direct regulation of STAT2 on PD-L1 through ChIP-seq profiles and cell experiments. (a) The mRNA expressions of STAT2 and PD-L1 were significantly correlated (r = 0.53, p < 0.05). (b) ChIP-seq profiles of STAT2 in colon cancer cell line revealed that STAT2 could directly bind to PD-L1 promoter. And there was a strong overlap between STAT2 binding sites and the predicted regions (Region 1 in dark blue, or Region 2 in light blue). (c) The knockdown of STAT2 could lead to downregulation of PD-L1 significantly (p < 0.05). (d) The overexpression of STAT2 could lead to upregulation of PD-L1 significantly (p < 0.05). *p < 0.05; ****p < 0.0001.