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. 2022 Aug 5;13(3):19476035221115541. doi: 10.1177/19476035221115541

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© The Author(s) 2022

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Figure 2. — Celecoxib reduces gene expression of proteolytic enzymes in cartilage ex vivo. ADAMTS4 (A), ADAMTS5 (B), MMP13 (C), AGC (D), and COL2A1 (E) mRNA expression levels in cartilage explants from OA patients treated with or without celecoxib. The median and range are plotted in the figures. Absolute P values are depicted in the figure. N = 7. ADAMTS4 = a disintegrin and metalloproteinase with thrombospondin motifs 4; ADAMTS5 = a disintegrin and metalloproteinase with thrombospondin motifs 5; MMP13 = metalloproteinase 13; AGC = aggrecan (protein); COL2A1 = collagen type 2 alpha 1; OA = osteoarthritis.