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. 2022 Jul 27;13:902881. doi: 10.3389/fimmu.2022.902881

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Copyright © 2022 Gao, Alisjahbana, Boey, Mohammad, Sleiers, Dahlin and Willinger

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proliferative CD117^-CRTH2^-CD45RA⁺ ILCs are present in the circulation and in human umbilical cord blood. (A) CD45RA surface expression by CD117^-CRTH2^- ILCs from the blood of HSPC-engrafted MISTRG mice, human umbilical cord blood, and human adult blood (n = 3). (B) Flow cytometry analysis of intracellular Ki67 expression by human CD117^-CRTH2^-CD34^-CD45RA⁺ ILCs, CRTH2⁺ ILC2s, and CD117⁺CRTH2^- ILC3s from the blood of HSPC-engrafted MISTRG mice as well as from human cord blood and human adult blood (n = 3). ILCs were gated as human CD45⁺CD127⁺CD94^-CD3^-TCRαβ^-Lin^- cells as in Supplementary Figure 1. (C) Frequencies of Ki67⁺ human CD117^-CRTH2^-CD34^-CD45RA⁺ and CD117^-CRTH2^-CD34^-CD45RA^- ILCs in human cord blood and adult blood (n = 3). *, P <0.05 by Student’s t test. Data represent mean ± SEM and are from three independent experiments.