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(a) Hyperkeratotic skin lesions on the soles in Case 3. (b) Apremilast resulted in a striking improvement of skin lesions within 3 months. (c) The yellowish hyperkeratosis and scaly erythema in Case 6. (d) Apremilast resulted in a striking improvement of palmoplantar keratoderma (PPK) within 2 months.
