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. Author manuscript; available in PMC: 2022 Aug 10.
Published in final edited form as: Immunohorizons. 2022 Feb 10;6(2):116–129. doi: 10.4049/immunohorizons.2000072

Figure 2.

Figure 2.

During Helicobacter pylori infection, both IL-17A and IL-17F can independently mediate acute inflammation, but the presence of either regulates chronic inflammation. A) Bacterial burden was measured in WT, Il17a−/−, Il17f−/−, Il17a/f−/− and Il17ra−/− mice that were infected with PMSS1 for 3 months (8-18 mice per genotype). Colony forming units (CFU) per gram of stomach tissues was calculated and is presented in the graph. Statistical analysis was performed using Dunnett’s Multiple comparisons test. B and C) Levels of acute and chronic inflammation were scored on stomach tissue (in the corpus and antrum) at 3 months post infection with strain PMSS1. Statistical analysis was performed using Kruskal-Wallis test, and error bars represented mean ± SEM. See methods for scoring system (scale is 0–12). *P ≤ 0.05, **P≤0.01, ****P≤0.0001. Data combines 2 independent experiments.