Table 2. Z-Average Size, Polydispersity Index (PDI), and ζ Potential Values of LPHFNPs, before and after Freeze-Drying in Bidistilled Water, and after Freeze-Drying in a 10 mM NaCl Solutiona.
| sample | Z-average (nm ± S.D.) | PDI ± S.D. | ζ Potential (mV ± S.D.) |
|---|---|---|---|
| Before Freeze-Drying/water | |||
| LPHFNPs | 82.8 ± 3.2 | 0.22 ± 0.01 | –8.8 ± 5.7 |
| LPHFNPs@Roflumilast | 110.8 ± 3.5 | 0.20 ± 0.11 | –9.9 ± 4.5 |
| Man-LPHFNPs | 72.1 ± 4.2 | 0.16 ± 0.04 | –21.4 ± 6.4 |
| Man-LPHFNPs@Roflumilast | 94.0 ± 1.3 | 0.15 ± 0.04 | –20.0 ± 5.9 |
| After Freeze-Drying/water | |||
| LPHFNPs | 91.4 ± 4.5 | 0.17 ± 0.01 | –8.7 ± 6.2 |
| LPHFNPs@Roflumilast | 114.6 ± 2.6 | 0.19 ± 0.03 | –9.6 ± 6.4 |
| Man-LPHFNPs | 88.5 ± 4.1 | 0.22 ± 0.08 | –18.8 ± 6.4 |
| Man-LPHFNPs@Roflumilast | 114.5 ± 1.6 | 0.20 ± 0.02 | –15.0 ± 5.1 |
| After Freeze-Drying/NaCl 10 mM | |||
| LPHFNPs | 169.8 ± 2.2 | 0.22 ± 0.04 | –7.4 ± 4.5 |
| LPHFNPs@Roflumilast | 222.4 ± 4.5 | 0.28 ± 0.10 | –9.6 ± 4.9 |
| Man-LPHFNPs | 159.1 ± 3.2 | 0.24 ± 0.03 | –7.5 ± 4.9 |
| Man-LPHFNPs@Roflumilast | 155.0 ± 1.7 | 0.25 ± 0.06 | –10.8 ± 5.6 |
a
Data are expressed as means ± SD (n = 3).