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. 2022 Jul 27;13:920227. doi: 10.3389/fimmu.2022.920227

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Copyright © 2022 Aiello, Grossi, Meschi, Meledandri, Vanini, Petrone, Casetti, Cuzzi, Salmi, Altera, Pierelli, Gualano, Ascoli Bartoli, Castilletti, Agrati, Girardi, Palmieri, Nicastri, Di Rosa and Goletti

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Plasmatic cytokines/chemokines modulated in household contacts at baseline. (A–H) Household contacts at T0 (n = 38) were stratified according to the swab result: positive (n = 10) and negative (n = 28). Plasma harvested from unstimulated blood samples were tested for the detection of 27 cytokines/chemokines using the Bio-Plex Pro Human Cytokine 27-plex Assay and for the detection of IFN-α and-β by means of an automatic ELISA. Red horizontal lines indicate medians. The green triangle identifies the subject with a positive swab only at T1. Statistical analysis was performed using Mann-Whitney U test to compare swab positive and negative subjects. A p < 0.05 was considered significant. IL, interleukin; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; IP, Interferon-gamma induced protein; RANTES, regulated on activation IFN, interferon.