Cytotoxicity of belinostat derivatives against MOPC-315 cell line.

Compd	A position	IC50 (μM)	Fold change
7a	4-Fluorobenzyl	0.457 ± 0.033	0.695
7b	4-Methylbenzyl	0.167 ± 0.014	1.907
7c	Benzyl	0.291 ± 0.044	1.093
7d	Cyclohexyl	0.444 ± 0.181	0.714
7e	5-Fluoro-2-methylphenyl	0.380 ± 0.073	0.835
7fa	4-Methoxyphenyl	0.090 ± 0.016	3.522
7g	4-Methylphenyl	0.159 ± 0.046	1.993
7h	4-Chloro-2-fluorophenyl	1.029 ± 0.469	0.309
7i	4-Fluorophenyl	0.312 ± 0.114	1.019
7j	2,4-Difluorophenyl	0.784 ± 0.198	0.405
7k	3-Fluorophenyl	0.365 ± 0.019	0.869
7l	(Z)-4-(1-(Hydroxyimino)ethyl)phenyl	2.141 ± 1.246	0.148
Belinostat b	Phenyl	0.318 ± 0.049	1.000

^aCompound 7f was chosen for further studies.

^bBelinostat was used as a positive control.