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. Author manuscript; available in PMC: 2022 Aug 10.

Published in final edited form as: Chem Biol Interact. 2022 Apr 14;360:109931. doi: 10.1016/j.cbi.2022.109931

Fig. 2. — A) Principal component analysis scores plot of control (•) and EtOH-consuming (•) mice. B) Volcano plot highlighting 304 significant ions. Metabolic features that were significantly (q ≤ 0.05, univariant analysis vs. control) upregulated (red dots) or down-regulated (blue dots) in EtOH-consuming mice are shown. For the X-axis, the threshold was log₂ fold-change ≥ |1| and for the Y-axis q-value ≤ 0.05. C) Heatmap of the 100 most highly significant metabolic features (i.e., m/z values) in individual control (C) and EtOH-consuming (Et) mice. Scale shows the log₁₀ fold-change in each metabolic feature using a range from −1.5 (blue) to +1.5 (red).

Fig. 2. — A) Principal component analysis scores plot of control (•) and EtOH-consuming (•) mice. B) Volcano plot highlighting 304 significant ions. Metabolic features that were significantly (q ≤ 0.05, univariant analysis vs. control) upregulated (red dots) or down-regulated (blue dots) in EtOH-consuming mice are shown. For the X-axis, the threshold was log₂ fold-change ≥ |1| and for the Y-axis q-value ≤ 0.05. C) Heatmap of the 100 most highly significant metabolic features (i.e., m/z values) in individual control (C) and EtOH-consuming (Et) mice. Scale shows the log₁₀ fold-change in each metabolic feature using a range from −1.5 (blue) to +1.5 (red).