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. 2022 Aug 10;20:119. doi: 10.1186/s12964-022-00925-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — TNC-induced post-translational stability of AR-V7 is not mediated by Integrin mediated FAK activation. A RT-qPCR analysis reveal that VCaP and 22Rv1 express integrin αv/2/9 and β1. B RT-qPCR analysis on expression of AR-V7, TNC, and AR-FL in VCaP and 22Rv1 cultured on BSA or TNC after integrin β1 knockdown using siRNA C Western blot analysis on the impact of integrin β1 knockdown on TNC signaling in VCaP and 22Rv1. SiRNA knockdown of integrin β1 impedes TNC-induced FAK activation but does not affect Src activation nor AR-V7 post-translational stability. All data represent mean ± SD analyzed by unpaired students t-test (n = 3); ** p < 0.01; ***p < 0.001; ****p < 0.0001