Table 2.
Univariate and multivariate analysis of Cox-proportional hazards model for the risk of 30-day mortality
| Univariate (HR, 95% CI) | P value | Multivariate (HR, 95% CI) | VIF | P value | |
|---|---|---|---|---|---|
| Age | 1.057 (1.030, 1.085) | < 0.001 | 1.066 (1.037, 1.095) | 1.3 | < 0.001 |
| Male | 0.973 (0.622, 1.521) | 0.904 | / | – | – |
| Laboratory tests | |||||
| WBC count | 1.025 (0.999, 1.052) | 0.063 | / | – | – |
| Neutrophil count | 1.034 (1.004, 1.065) | 0.026 | / | – | / |
| Lymphocyte count | 0.886 (0.709, 1.107) | 0.287 | / | – | – |
| Platelet count | 1.000 (0.998, 1.002) | 0.779 | – | – | – |
| Hemoglobin | 0.930 (0.829, 1.043) | 0.213 | – | – | – |
| Serum albumin | 0.547 (0.379, 0.787) | 0.001 | – | – | – |
| Serum sodium | 0.995 (0.954, 1.037) | 0.799 | – | – | – |
| Serum potassium | 0.772 (0.580, 1.027) | 0.076 | – | – | – |
| Serum calcium | 1.257 (0.056, 28.164) | 0.885 | – | – | – |
| pH | 0.474 (0.059, 3.820) | 0.483 | – | – | – |
| pO2 | 0.998 (0.996, 1.000) | 0.079 | 0.997 (0.995, 0.999) | 1.1 | 0.009 |
| pCO2 | 1.000 (0.990, 1.011) | 0.957 | – | – | – |
| Bicarbonate | 1.010 (0.975, 1.045) | 0.588 | – | – | – |
| ALT | 0.999 (0.997, 1.001) | 0.409 | – | – | – |
| AST | 0.999 (0.997, 1.001) | 0.484 | – | – | – |
| Serum creatinine | 1.058 (0.881, 1.270) | 0.547 | – | – | – |
| BUN | 1.006 (0.997, 1.015) | 0.192 | – | – | – |
| Mean vital signs | |||||
| Temperature | 0.934 (0.641, 1.361) | 0.723 | – | – | – |
| MAP | 0.984 (0.962, 1.007) | 0.175 | – | – | – |
| Heart rate | 1.012 (0.997, 1.028) | 0.122 | – | – | – |
| Respiratory rate | 1.018 (0.964, 1.075) | 0.524 | – | – | – |
| Comorbidities | |||||
| Hypertension | 0.635 (0.402, 1.004) | 0.052 | – | – | – |
| DM | 0.710 (0.581, 1.025) | 0.056 | – | – | – |
| CHD | 1.383 (0.697, 1.745) | 0.225 | – | – | – |
| CKD | 0.564 (0.271, 1.173) | 0.125 | – | – | – |
| Malignancy | 1.190 (0.731, 1.939) | 0.484 | – | – | – |
| Inflammatory indicators | |||||
| NLR | 1.009 (1.003, 1.016) | 0.006 | 1.006 (1.001, 1.013) | 1.4 | 0.048 |
| PLR | 1.000 (1.000, 1.001) | 0.108 | – | – | – |
| PNI | 0.941 (0.908, 0.975) | < 0.001 | 0.958 (0.923, 0.994) | 1.0 | 0.024 |
| Scoring system | |||||
| SAPSII | 1.037 (1.020, 1.054) | < 0.001 | – | – | – |
| SOFA | 1.099 (1.020, 1.184) | 0.013 | – | – | – |
| Treatment | |||||
| MV | 2.602 (1.339, 5.057) | 0.005 | 2.516 (1.265, 5.005) | 1.2 | 0.008 |
| Vasopressor | 2.206 (1.408, 3.455) | < 0.001 | 2.042 (1.267, 3.292) | 1.4 | 0.003 |
ALT alanine transaminase, AST aspartate transaminase, BUN blood urea nitrogen, CHD coronary heart disease, CKD, chronic kidney disease, DM diabetes mellitus, IMV invasive mechanical ventilation, MAP mean atrial pressure, NLR neutrophil-to-lymphocyte ratio PLR platelet-to-lymphocyte ratio, PNI prognostic nutritional index, SAPSII simplified acute physiology score II, SOFA sequential organ failure assessment, VIF variance inflation factor, WBC white blood cell