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. 2022 Aug 10;17:13. doi: 10.1186/s12263-022-00714-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — DEGs in the CC were associated with obesity-related traits in humans. Comparisons of differentially expressed genes, genes with expression levels significantly correlated with body fat % (BF%), and genes previously found to be associated with obesity-related traits in the GWAS catalog revealed A the number of genes differentially expressed by diet that also had expression levels significantly correlated with body fat % and associated with obesity traits in humans (65), B the number of genes differentially expressed by CC strain that also had expression levels significantly correlated with body fat % and associated with obesity traits in humans (431), and C the number of genes that fall under all four categories (62). Gene annotation, body fat % correlations, limma statistics, and a subset of related GWAS annotation are shown for the 65 diet DEGs in Supplementary Table 7 and 431 strain DEGs in Supplementary Table 8 (see Additional file 2)