Fig. 6.

Modules enriched for distinct liver functions were also correlated with body fat %. Enrichr analysis performed using the most recent versions of respective databases identified the top significant enrichment for each module, if available; genes belonging to the tan module did not show any significant enrichment. A All modules showed significant enrichment for at least one GO biological process, except for the tan and pink modules. B Similarly, all modules showed significant enrichment for at least one GO molecular function, except for the tan and salmon modules. Fewer modules were enriched for C KEGG pathways and D Jensen diseases. Spearman’s correlations between post-diet body fat % and E yellow ME (PC1) (rho = −0.28, p = 0.0016), F magenta ME (PC1) (rho = 0.19, p = 0.037), and G red ME (PC1) (rho = 0.27, p = 0.0027) show significant overall associations between average expression profiles of modules identified by WGCNA and body fat %