Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 10;23(1):98. doi: 10.1186/s10194-022-01469-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Effect of quinpirole on pain thresholds and GLUA1 trafficking in CM rats. A B and C Pain thresholds were increased after quinpirole (1 µg and 10 µg) administration in CM rats in a dose-dependent manner. Two-way ANOVA with the Bonferroni post hoc test. n = 6/group. **P < 0.01, ***P < 0.001 vs. the Sham group; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. the CM + DMSO group. D and E Western blot showing enhanced GLUA1 trafficking and increased phosphorylation levels in the CM group, which were abolished by DRD2 agonist treatment; the total GLUA1 level was unchanged. p-GLUA1, m-GLUA1 and t-GLUA1 represent the phosphorylated, plasma membrane and total levels of GLUA1 respectively. p/t-GLUA1 represents the p-GLUA1/t-GLUA1 value; m/t-GLUA1 represents the (m-GLUA1/N-cadherin)/(t-GLUA1/GAPDH) value. F and G The increases in the protein levels of PSD95 and phosphorylated ERK in CM rats were dramatically inhibited by quinpirole, as shown by western blot analysis. One-way ANOVA with Dunnett’s post hoc test; n = 6/group. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the Sham group; ##P < 0.01, ###P < 0.001 vs. the CM + DMSO group