Table 2.
Incidence of primary and secondary outcomes in groups divided based on cutoff values
| Trough < 13.94 μg/mL (n = 37) | Trough ≥ 13.94 μg/mL (n = 28) | Odds ratio | p-value | |
|---|---|---|---|---|
| 30-day mortality | 1 (2.7%) | 8 (28.6%) | 14.40 (1.68–123.56) | 0.004 |
| Treatment failure at EOT (n = 64)* | 7 (19.4%) | 8 (28.6%) | 1.65 (0.51–5.30) | 0.553 |
| Nephrotoxicity (n = 63)** | 3 (8.1%) | 11 (39.3%) | 7.33 (1.80–29.83) | 0.005 |
| 90-day recurrence (n = 64)*** | 4 (10.8%) | 3 (11.1%) | 1.08 (0.22–5.27) | > 0.999 |
| AUC24/MIC < 504 (n = 22) | AUC24/MIC ≥ 504 (n = 43) | Odds ratio | p-value | |
|---|---|---|---|---|
| 30-day mortality | 0 (0.0%) | 9 (20.9%) | N/A | 0.023 |
| Treatment failure at EOT (n = 64)* | 3 (13.6%) | 12 (27.9%) | 2.23 (0.58–9.34) | 0.348 |
| Nephrotoxicity (n = 63)** | 2 (9.1%) | 12 (27.9%) | 3.87 (0.78–19.15) | 0.114 |
| 90-day recurrence (n = 64)*** | 2 (9.1%) | 5 (11.9%) | 1.39 (0.25–7.82) | > 0.999 |
EOT, end of treatment; ICU, intensive care unit; N/A: not applicable; MIC, minimum inhibitory concentration; AUC24, area under the curve during 24 h
*One patient whose treatment outcome was not assessable for having been referred to another hospital for the remaining treatment was excluded
**Two patients who were already in the ICU at the onset of bacteremia were not included
***One patient who died within 90 days without clearance of bacteremia was not included