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. 2022 Jul 22;10:882416. doi: 10.3389/fped.2022.882416

Table 3.

Age at presentation of symptoms, NSC score and antibiotics.

Late preterm neonates
(n = 178)
Full term neonates
(n = 3,267)
p All
(n = 3,445)
Neonates with symptoms 53 (29.78) 211 (6.46) <0.0001 264 (7.66)
    Neonates with symptoms already at birth 46 (86.79) 134 (63.51) 180 (68.18)
    Neonates with symptoms from 1 to 6 h of life 5 (9.43) 44 (20.85) 0.0044 49 (18.56)
    Neonates with symptoms after 6 h of life 2 (3.77) 33 (15.64) 35 (13.26)
Serial clinical observation 56 (31.46) 301 (9.21) <0.0001 357 (10.4)
Evaluation to rule out sepsis 33 (18.54) 104 (3.18) <0.0001 137 (3.98)
NSC score <0.5 117 (70.06) 3,146 (96.30) <0.0001 3,263 (94.72)
NSC score > 0.51 <1 11 (6.59) 46 (1.41) <0.0001 57 (1.65)
NSC score > 1.01 <3 16 (9.58) 46 (1.41) <0.0001 62 (1.80)
NSC score > 3.01 23 (13.77) 29 (0.89) <0.0001 52 (1.51)
Neonates given antibiotics 15 (8.43) 49 (1.49) <0.0001 64 (1.86)
Median days on antibiotics 2 (2–2) 3 (2–3) 0.0637 2 (2–3)
Symptomatic neonates admitted to NICU § 35 (19.66) 73 (2.23) <0.0001 108 (3.13)
Symptomatic neonates admitted to intermediate care unit § 17 (9.55%) 62 (1.90%) <0.0001 79 (2.30%)
Symptomatic neonates unadmitted to NICU or intermediate care unit ¥ 1 (0.06 %) 76 (2.33%) 0.1209 77 (2.24%)

NICU, neonatal intensive care unit; NSC, neonatal sepsis calculator.

Including white blood cell count, blood culture, and C-reactive protein.

Among 64 neonates receiving antibiotics, 14 underwent therapeutic hypothermia and 6 had surgical prophylaxis.

§

Antibiotics were given to 55 out of 108 symptomatic neonates admitted to NICU and 9 out of 79 admitted to intermediate care unit; “rule out sepsis” was performed in all symptomatic neonates admitted to NICU.

¥

“Rooming in” was allowed within a few hours of birth to all 77 neonates and they were discharged home with a “healthy newborn” code.

Data are presented as median (IQR) or n (%).