Table 3.
Age at presentation of symptoms, NSC score and antibiotics.
|
Late preterm neonates (n = 178) |
Full term neonates (n = 3,267) |
p |
All (n = 3,445) |
|
|---|---|---|---|---|
| Neonates with symptoms | 53 (29.78) | 211 (6.46) | <0.0001 | 264 (7.66) |
| Neonates with symptoms already at birth | 46 (86.79) | 134 (63.51) | 180 (68.18) | |
| Neonates with symptoms from 1 to 6 h of life | 5 (9.43) | 44 (20.85) | 0.0044 | 49 (18.56) |
| Neonates with symptoms after 6 h of life | 2 (3.77) | 33 (15.64) | 35 (13.26) | |
| Serial clinical observation | 56 (31.46) | 301 (9.21) | <0.0001 | 357 (10.4) |
| Evaluation to rule out sepsis † | 33 (18.54) | 104 (3.18) | <0.0001 | 137 (3.98) |
| NSC score <0.5 | 117 (70.06) | 3,146 (96.30) | <0.0001 | 3,263 (94.72) |
| NSC score > 0.51 <1 | 11 (6.59) | 46 (1.41) | <0.0001 | 57 (1.65) |
| NSC score > 1.01 <3 | 16 (9.58) | 46 (1.41) | <0.0001 | 62 (1.80) |
| NSC score > 3.01 | 23 (13.77) | 29 (0.89) | <0.0001 | 52 (1.51) |
| Neonates given antibiotics ¶ | 15 (8.43) | 49 (1.49) | <0.0001 | 64 (1.86) |
| Median days on antibiotics | 2 (2–2) | 3 (2–3) | 0.0637 | 2 (2–3) |
| Symptomatic neonates admitted to NICU § | 35 (19.66) | 73 (2.23) | <0.0001 | 108 (3.13) |
| Symptomatic neonates admitted to intermediate care unit § | 17 (9.55%) | 62 (1.90%) | <0.0001 | 79 (2.30%) |
| Symptomatic neonates unadmitted to NICU or intermediate care unit ¥ | 1 (0.06 %) | 76 (2.33%) | 0.1209 | 77 (2.24%) |
NICU, neonatal intensive care unit; NSC, neonatal sepsis calculator.
Including white blood cell count, blood culture, and C-reactive protein.
Among 64 neonates receiving antibiotics, 14 underwent therapeutic hypothermia and 6 had surgical prophylaxis.
Antibiotics were given to 55 out of 108 symptomatic neonates admitted to NICU and 9 out of 79 admitted to intermediate care unit; “rule out sepsis” was performed in all symptomatic neonates admitted to NICU.
“Rooming in” was allowed within a few hours of birth to all 77 neonates and they were discharged home with a “healthy newborn” code.
Data are presented as median (IQR) or n (%).