Table 2.
Genes responsible for immunomodulatory functions found in OV variants.
| Affected Immune Function | Pertinent HSV-1 OV Gene | Immunomodulatory Effect of Protein Product | HSV-1 OV Variants with Modification |
|---|---|---|---|
| Antigen Presentation | UL34.5 | -Inhibition of immune cell activation via interference with macroautophagy by infected cell -Inhibition of immune cell activation via interference with MHC II expression by infected cell |
T-VEC, HSV1716, G207, M032 |
| UL47 | -Inhibition of CTL activation via interference with TAP function | T-VEC, G47Δ | |
| UL49.5 | -Inhibition of CTL activation via interference with TAP function | HF10 | |
| Inflammation | US11 | -Inhibition of innate antiviral responses (enhanced expression due to deletion of UL47) | T-VEC, G47Δ |
| UL24 | -Inhibition of innate immune inflammatory response via interference with activation of NF-κB | NV1020 | |
| Inflammation | GM-CSF | -Recruitment of immune cells for enhancement of bystander effect | T-VEC |
| IL-12 | -Enhancement of NK cell cytolytic activity; polarization of immune response towards Th1-type response | M032 |