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. 2022 Aug 6;27(1):167–175. doi: 10.1080/13510002.2022.2102843

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Effects of the Cdc42-WASP-Arp2/3 pathway on ROS production and apoptosis. Cells were treated with Cdc42-WASP-Arp2/3 pathway inhibitor (ML141) and activator (CN02) treatment. (A and B) Western blot to detect the expression levels of DOCK8, p-WASP, WASP, Arp2, Arp3 and F-actin. (C) Statistical analysis of the percentage of DCF-positive cells and their MFI. (D and E) FACSCalibur flow cytometer images and statistical analysis of apoptosis rate. (F) Levels of SOD, CAT and GSH-PX in each group. Compared with the ML141-untreated (ML141-) group, *P < 0.05, **P < 0.01, ***P < 0.001. Compared with the CN02-untreated (CN02-) group, ^#P < 0.05, ^##P < 0.01, ^###P < 0.001.