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. 2022 Jul 22;13:952338. doi: 10.3389/fimmu.2022.952338

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Copyright © 2022 Su, Zhang, Yang, Tang, Shen, Liu, Ji, Maurer and Jiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gal-9 inhibits the proliferation and induces apoptosis in PBMCs from AD patients. (A) CCK-8 assay and (B) Apoptosis assay of PBMCs isolated from AD patients (Mild AD, n=11; Moderate AD, n=9; Severe AD, n=10) under graded doses of Gal-9 (0, 1.5, 5, 15, and 50 nM) and anti-CD3(100ng/ml) for 72 h, respectively. These results are presented as means ± SEM. *P <0.05, **P <0.01, ***P <0.001 Mild AD vs. Moderate AD; #P < 0.05, ##P < 0.01, ###P < 0.001 Mild AD vs. Severe AD. ζP < 0.05, ζζP < 0.01, ζζζP < 0.001 Moderate AD vs. Severe AD.