Fig. 5. Sub-clustering of endothelial cells.
a, Sub-clusters of human endothelial (endo) cells using the integrated snRNA-seq and snATAC-seq data. b, Comparison of capillary endothelial cells and lymphatic endothelial cell proportion between donor and patient groups. Wilcoxon rank-sum test (unpaired, two-sided; myogenic: n = 13, ischaemic: n = 7, fibrotic: n = 4). c, Median importance of the abundance of major cell types within a spot (left) and the local neighbourhood (effective radius of 5 spots) (right) in the prediction of endothelial cell-state scores in spatial transcriptomics. d, Spatial distribution of the abundance of vSMCs and the state score of arterial endothelial cells in an ischaemic (left) and control (right) sample. Arrows point at colocalization events. For details on visualization, statistics and reproducibility, see Methods.