FIGURE 4.

Theoretic and actual doses administered in multitreatment strategy. (A) Total calculated dose in kilobecquerels given compared with amount found in tumor with initial dose of 1.85 kBq followed by 5 subsequent doses of 0.70 kBq (Fig. 1). (B) Total calculated amount of radioactivity in tumor, accounting for radioactive decay. (C) Actual injected dose in kilobecquerels determined by ¹¹¹In-DOTAylated-huCC49 biodistribution performed after each dose of ²²⁵Ac-DOTAylated-huCC49 compared with amount in tumor, where initial dose is 1.85 kBq followed by 5 subsequent doses of 0.70 kBq. (D) Total actual amount of radioactivity in tumor, accounting for radioactive decay.