TABLE 1.
Mean Survival and Total Absorbed Tumor Dose for 225Ac Radioimmunotherapy of OVCAR3 Xenografts
| Parameter | Control* (n = 16) | 7.4 kBq untargeted antibody (n = 6) | 1.85 kBq huCC49 (n = 6) | 3.7 kBq huCC49 (n = 6) | 7.4 kBq huCC49 (n = 6) | Multitreatment untargeted antibody (n = 8) | Multitreatment huCC49 (n = 8) |
| Mean survival | 32.3 | 87.9† | 54.6† | 81.6† | 103† | 37.6 (NS) | 86.0 |
| Maximum tumor dose (Gy)‡ | NA | 2.93 | 2.50 | 5.01 | 10.0 | 7.74 | 17.7 |
| Minimum tumor dose (Gy)¶ | NA | 0.73 | 0.63 | 1.25 | 2.50 | 1.94 | 4.43 |
*
Number of radioimmunotherapy controls combined from single and multitreatment groups.
†
Significant difference from no radioimmunotherapy controls.
‡
Assuming delivery of all 4 α-particles at site of tumor based on biodistribution study.
¶
Assuming delivery of only 1 α-particle at site of tumor based on biodistribution study.
NA = not applicable; NS = not statistically significant.