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Mice carrying the Dmp1-hSOST transgene do not respond to mechanical stimulation of the ulna. (Left) Histological photomicrographs of the loaded and nonloaded ulnae in transgenic and nontransgenic mice, illustrating the paucity of labeling in transgenic mice. (Right) Quantification of periosteal relative bone formation rates per unit bone surface (rBFR/BS) in the ulnae was significantly reduced in transgenic mice.
