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. 2022 Aug 4;30(8):1098–1108.e6. doi: 10.1016/j.str.2022.05.007

Figure 2.

Figure 2

Overlay of the [IGF-I]-bound HybZip structure onto the single-liganded structures of the corresponding homodimer receptors

(A and E) Overlay of [IGF-I]-bound HybZip onto [IGF-I]-bound IGF-1R (PDB: 6PYH).

(B and F) Overlay of [IGF-I]-bound HybZip onto [IGF-II]-bound IGF-1R (closed-leg form; PDB: 6VWI).

(C and G) Overlay of [IGF-I]-bound HybZip onto [single-insulin]-bound IR (PDB: 6HN5).

(D and H) Overlay of [IGF-I]-bound HybZip onto insulin-bound IGF-1R (PDB: 6JK8).

In all panels, [IGF-I]-bound HybZip is displayed as colored ribbon, and the liganded homodimeric receptor is displayed as gray ribbon. Overlays are based on the common domain L1 (light blue surface).