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. 2022 Aug 4;30(8):1098–1108.e6. doi: 10.1016/j.str.2022.05.007

Figure 4.

Figure 4

Arrangement of the αCT segments within [IGF-I]-complexed HybZip

(A) Schematic showing the close correspondence of the IR αCT segment on IGF-1R domain L1 within the context of [IGF-I]-bound HybZip with that of the IGF-1R αCT segment within the context of [IGF-I]-bound IGF-1R.

(B) Schematic showing putative salt bridges formed by the IR αCT segment with adjacent domains IGF-1R L2 and IR FnIII-1 within the context of [IGF-I]-bound HybZip.

(C) Schematic showing the close correspondence of the IGF-1R αCT segment on IR domain L1 within the context of [IGF-I]-bound HybZip with that of the IGF-1R αCT segment within the context of apo IGF-1R.