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. Author manuscript; available in PMC: 2022 Aug 10.
Published in final edited form as: Transl Perioper Pain Med. 2022 Jun 29;9(2):452–457.

Figure 1:

Figure 1:

Chemical structures of salvinorin A and some well-known analogues of salvinorin A. Herkinorin, PR-38, salvindolin, compound 1, and compound 2 (now known as salvidenin) are dual KOR/MOR agonists. RB-64 is a G-protein-biased KOR agonist that forms a covalent bond with KOR. β-Tetrahydropyran salvinorin B is a long-acting KOR agonist. 16-Ethynyl salvinorin A is a nonbiased KOR agonist. 16-Bromo salvinorin A is a G-protein-biased KOR agonist. 1α-Hydroxysalvinorin A is a KOR antagonist. KOR, kappa opioid receptor. MOR, mu opioid receptor.