Table 3.
Multivariate Cox regression analysis showing the risk factors associated with graft failure in the IgAN group
| Risk factors | Hazard ratio | 95% Confidence interval | P |
|---|---|---|---|
| Recipient age (per year) | 0.98 | 0.94-1.04 | 0.67 |
| Recipient sex (male vs. female) | 0.96 | 0.125-7.36 | 0.96 |
| Dialysis vintage (per year) | 1.04 | 0.97-1.11 | 0.19 |
| Time of recurrence (per year) | 3.95 | 0.81-19.15 | 0.87 |
| Renal biopsy | |||
| Mesangial proliferation | 0.57 | 0.23-1.4 | 0.22 |
| Endocapillary proliferation | 0.55 | 0.73-4.19 | 0.56 |
| Segmental sclerosis | 1.76 | 0.68-4.4 | 0.23 |
| Tubular atrophy | 1.66 | 0.59-4.67 | 0.33 |
| Crescents | 0.97 | 0.12-7.59 | 0.98 |
| HLA mismatch (per mismatch) | 0.87 | 0.30-2.49 | 0.80 |
| Donor age (per year) | 1.00 | 0.96-1.05 | 0.78 |
| Donor sex (male vs. female) | 0.65 | 011-1.98 | 0.43 |
| Donor GFR (per mL/minute) | 0.99 | 0.90-1.10 | 0.96 |
| Proteinuria (per g/day) | 1.09 | 0.88-1.34 | 0.40 |
| Creatinine at 1 year | 4.6 | 0.30-57.69 | 0.23 |
| Creatinine at 5 year | 2.18 | 1.34-3.55 | 0.002 |
| Chronic ABMR | 0.89 | 0.34-2.33 | 0.82 |
| Acute rejections | 4.95 | 0.82-29.93 | 0.08 |
| CMV infection | 1.42 | 0.48-4.19 | 0.51 |
| Induction regimen (ATG vs. Basiliximab) | 0.627 | 0.15-2.55 | 0.51 |
| Tacrolimus vs. Cyclosporine based | 0.421 | 0.94-1.89 | 0.25 |
IgAN=immunoglobulin A nephropathy, HLA=human leukocyte antigens, GFR=glomerular filtration rate, ABMR=antibody-mediated rejection, CMV=cytomegalovirus, ATG=antithymocyte globulin