Table 2.
Subnetworks identified to be significantly different among the DM, pED, DM-ED, and HC groups using network-based statistical analysis.
| Subnetwork | Edge | t | P | |
|---|---|---|---|---|
| Node 1 | Node 2 | |||
| DM < HCs | Right middle frontal gyrus (orbital part) | Right thalamus | 2.76 | <0.05 |
| Right middle frontal gyrus (orbital part) | Right putamen | 3.43 | <0.05 | |
| Right middle frontal gyrus (orbital part) | Right caudate nucleus | 3.30 | <0.05 | |
| DM > HCs | No significant edge was found | |||
| pED < HCs | Left superior frontal gyrus (medial orbital) | Right superior frontal gyrus (orbital part) | 2.53 | <0.05 |
| Right superior frontal gyrus (orbital part) | Right inferior frontal gyrus (orbital part) | 3.21 | <0.05 | |
| Right inferior frontal gyrus (orbital part) | Right middle frontal gyrus (orbital part) | 4.22 | <0.05 | |
| Right middle frontal gyrus (orbital part) | Right putamen | 2.52 | <0.05 | |
| pED > HCs | No significant edge was found | |||
| DM-ED < HCs | Right middle frontal gyrus (orbital part) | Right thalamus | 2.81 | <0.05 |
| Right middle frontal gyrus (orbital part) | Right putamen | 3.78 | <0.05 | |
| Right thalamus | Right putamen | 3.74 | <0.05 | |
| Right thalamus | Right pallidum | 3.12 | <0.05 | |
| DM-ED > HCs | No significant edge was found | |||
| DM < DM-ED | Right superior parietal gyrus | Right inferior parietal gyrus | 3.26 | <0.05 |
| Right inferior parietal gyrus | Right postcentral gyrus | 3.16 | <0.05 | |
| Right superior parietal gyrus | Right angular gyrus | 3.18 | <0.05 | |
| Right superior parietal gyrus | Right superior occipital gyrus | 2.91 | <0.05 | |
| DM > DM-ED | No significant edge was found | |||
| pED < DM-ED | Left middle frontal gyrus | Left caudate nucleus | 4.21 | <0.05 |
| Left middle frontal gyrus | Left anterior cingulate gyrus | 3.16 | <0.05 | |
| Left anterior cingulate gyrus | Right median cingulate gyrus | 2.70 | <0.05 | |
| Right median cingulate gyrus | Right postcentral gyrus | 2.90 | <0.05 | |
| pED > DM-ED | No significant edge was found | |||
To identify the significance of each subnetwork, nonparametric permutation statistic (test statistic threshold = 2.5; 5,000 permutations; P < 0.05) was performed with network-based statistical correction, and network size was measured with intensity.
DM, diabetes mellitus; pED, psychological erectile dysfunction; DM-ED, diabetic erectile dysfunction; HC, healthy controls.