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. 2022 Aug 6;15:1561–1573. doi: 10.2147/CCID.S374128

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© 2022 Zhou et al.

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R-PGRN promotes the functional activation and differentiation of fibroblasts by activating the TGF-β/SMAD signaling pathway. (A) The expression of collagen types I (COL-I) and III (COL-III), α-SMA, TGF-β1 and p-SMAD2&3 in different groups were detected by Western blot analysis. Actin served as a control. (B) The expressions of COL-I and COL-III, α-SMA, TGF-β1 and p-SMAD2&3 in different groups were detected by Western blot analysis after pretreatment with HY-10431 or not. GAPDH served as a control. Data are shown as the mean ± SEM (n = 3) (*p < 0.05 vs control).