Table 1.
Examples of ion flux-independent NMDAR signaling
| Phenomenon | Agonist | Co-agonist | Agonist + Co-agonist |
Other | References |
|---|---|---|---|---|---|
| NEURONAL PHYSIOLOGY | |||||
| NMDAR endocytosis/ trafficking | x | Vissel 2001, Barria 2002 | |||
| x | Nong 2003, Papouin 2012, Han 2013, Ferreira 2017, Li 2021 | ||||
| Synaptic plasticity | x | Nabavi 2013, Aow 2015, Stein 2015, Carter 2016, Wong 2018, Dore 2020, Stein 2020 | |||
| Spine structural plasticity | x | Stein 2015, Stein 2020, Thomazeau 2020, Stein 2021 | |||
| Synaptic transmission | x | Li 2016b | |||
| x | ** | Abrahamsson 2017 | |||
| x | Bialecki 2020 | ||||
| Synapse to nucleus gene expression | x | DHPG | Yang 2004 | ||
| NON-NEURONAL PHYSIOLOGY | |||||
| Astrocytic ER Ca2+ release | x | Montes de Oca Balderas 2015, Montes de Oca Balderas 2020 | |||
| BBB permeability | x | x | tPA | Mehra 2020 | |
| NEURONAL DYSFUNCTION & DISEASE | |||||
| Excitotoxicity | |||||
| Inhibition of protein synthesis | x | Gauchy 2002 | |||
| Mitochondrial dysfunction | x | Weilinger 2016 | |||
| Superoxide production | x | Minnella 2018 | |||
| Cerebral ischemia/Traumatic brain injury | |||||
| Neuroprotection | x | Hu 2016, Chen 2017 | |||
| Alzheimer's disease | |||||
| Synaptic weakening | β-amyloid | Kessels 2013, Tamburri 2013, Dore 2021 | |||
| Spine structural plasticity | β-amyloid | Birnbaum 2015 | |||
| Schizophrenia | |||||
| Spine structural plasticity | x | Park 2021 | |||
**
not tested