Table 1. Comparison of protein concentrations from peripheral blood samples of 42 TAMC healthy controls obtained in-clinic using the Tasso SST (capillary serum) and phlebotomy (venous serum and plasma).
Up to 5 samples were collected from each participant over a 28-day period and are aggregated here. Concentrations are given as the median and interquartile range, and sorted by adjusted Kruskal-Wallis test q-values. *Note the high proportion of samples with IL-1B and IL-5 concentrations below the LLoQ. Boxplots of individual proteins with between-group significance are given in S1 Fig.
| Protein concentrations in matched samples from healthy controls | |||||
|---|---|---|---|---|---|
| TAMC in-clinic supervised collection—all time points | |||||
| Analyte | N | Tasso SST serum | Venous serum | Venous plasma | KW test |
| CRP | 183 | 0.80 μg/ml (0.39–1.82) | 0.86 μg/ml (0.41–2.04) | 0.87 μg/ml (0.41–1.97) | 0.932 |
| CD163 | 152 | 431 ng/ml (314–557) | 431 ng/ml (309–569) | 404 ng/ml (294–547) | 0.662 |
| IL-6 | 183 | 1.48 pg/ml (0.89–2.36) | 1.36 pg/ml (0.87–2.13) | 1.35 pg/ml (0.90–2.09) | 0.662 |
| IL-18BPa | 152 | 4.28 ng/ml (3.77–5.61) | 4.46 ng/ml (3.93–5.98) | 4.38 ng/ml (3.79–5.78) | 0.577 |
| PCT | 183 | 60.8 pg/ml (40.4–80.7) | 56.4 pg/ml (37.6–79.3) | 56.1 pg/ml (37.5–80.0) | 0.497 |
| RAGE | 183 | 0.91 ng/ml (0.75–1.13) | 0.95 ng/ml (0.78–1.18) | 0.97 pg/ml (0.77–1.22) | 0.392 |
| ICAM-1 | 183 | 292 ng/ml (248–340) | 301 ng/ml (264–349) | 294 ng/ml (254–344) | 0.338 |
| IL-6Ra | 183 | 45.4 ng/ml (38.4–52.0) | 47.1 ng/ml (40.2–53.0) | 48.1 ng/ml (40.2–54.2) | 0.113 |
| Ferritin | 183 | 101 ng/ml (60–161) | 76 ng/ml (41–148) | 74 ng/ml (37–139) | 0.004 |
| LCN | 183 | 76.6 ng/ml (64.1–90.4) | 76.4 ng/ml (66.2–87.7) | 70.8 ng/ml (60.8–78.0) | 4.4E-05 |
| CXCL10 | 152 | 111 pg/ml (86–164) | 107 pg/ml (74–150) | 87 pg/ml (57–122) | 3.3E-08 |
| IL-5* | 183 | 0.13 pg/ml (0–0.28) | 0.11 pg/ml (0–0.26) | 0.25 pg/ml (0.12–0.45) | 7.5E-09 |
| TNF-R1 | 183 | 0.97 ng/ml (0.82–1.10) | 0.89 ng/ml (0.77–1.02) | 0.82 pg/ml (0.72–0.96) | 1.4E-10 |
| IL-1B* | 183 | 0.02 pg/ml (0–0.44) | 0 pg/ml (0–0) | 0.02 pg/ml (0–0.13) | 3.4E-11 |
| D-dimer | 183 | 0.22 μg/ml (0.35–0.44) | 0.13 μg/ml (0.09–0.23) | 0.26 μg/ml (0.17–0.39) | 2.7E-13 |
| VEGF-A | 183 | 140 pg/ml (89–236) | 104 pg/ml (60–182) | 29 pg/ml (23–40) | 2.1E-64 |
| IL-1Ra | 183 | 1.58 ng/ml (1.12–2.14) | 0.26 ng/ml (0.20–0.37) | 0.21 ng/ml (0.15–0.31) | 1.7E-78 |