Table 3.

Associations of mutually adjusted CMR metrics with incident cardiovascular disease and mortality outcomes in Cox proportional hazard models with full confounder adjustment

CMR metric	AF	Stroke	IHD	MI	All-cause mortality	CVD mortality
LAVi (mL/m2)	1.47*	1.13	1.10	1.06	1.11	1.34*
	(1.28–1.70)	(0.98–1.31)	(1.01–1.19)	(0.93–1.21)	(1.00–1.23)	(1.05–1.71)
	8.46 × 10−8	0.0807	0.0302	0.4002	0.0407	0.0185
LAEF (%)	0.64*	0.83*	0.88*	0.87*	0.96	0.85
	(0.56–0.73)	(0.73–0.95)	(0.81–0.95)	(0.76–0.99)	(0.87–1.06)	(0.69–1.04)
	2.50 × 10−11	0.0060	9.95 × 10−4	0.0294	0.4029	0.1119
LVM : LVEDV	1.06	1.22*	1.27*	1.14	1.09	1.05
	(0.92–1.23)	(1.06–1.40)	(1.17–1.37)	(0.99–1.30)	(0.98–1.22)	(0.82–1.35)
	0.4036	0.0065	1.27x10−8	0.0732	0.0959	0.7039
LVGFI (%)	0.92	0.89	0.88*	0.95	0.85*	0.61*
	(0.79–1.06)	(0.76–1.03)	(0.80–0.96)	(0.82–1.11)	(0.76–0.95)	(0.48–0.78)
	0.2521	0.1266	0.0063	0.5372	0.0050	5.95 × 10−5
GLS (%)	0.97	1.10	1.08	1.05	1.14*	1.10
	(0.85–1.12)	(0.95–1.27)	(0.99–1.17)	(0.91–1.20)	(1.02–1.27)	(0.87–1.38)
	0.7171	0.1880	0.0888	0.5254	0.0170	0.4314

Results are hazard ratios, 95% confidence intervals, and P-values. Covariates are LAV, LAEF, LVM/LVEDV, GLS, GLFI, age, sex, ethnicity, deprivation, education, body mass index, hypertension, high cholesterol, diabetes, physical activity, and smoking. The CMR variables are principal component analysis rotated variables.

AF, atrial fibrillation; CMR, cardiovascular magnetic resonance; CVD, cardiovascular disease; LVGFI, left ventricular global function index; GLS, global longitudinal strain; i, indicates indexation to body surface area; IHD, ischaemic heart disease; LAEF, left atrial ejection fraction; LAV, maximum left atrial volume; LVEDV, left ventricular end-diastolic volume; LVM, left ventricular mass; MI, myocardial infarction.

^*Statistically significant P-values with a false discovery rate of 0.05, giving an approximate threshold of 0.028.