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. 2022 Jan 24;28(7):1446–1459. doi: 10.1158/1078-0432.CCR-21-1846

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 6. DNA-PK regulation of glycolysis contributes to aggressive disease and can be mitigated by co-targeting DNA-PK and glycolysis. A, ALDOA and PKM2 overexpression rescue blunted proliferation by DNA-PK inhibition. B, Co-targeting DNA-PK and glycolysis has additive anti-proliferative effect when using titrating DNA-PKi and 2-DG concentration (0–25 μmol/L). C, Summary schematic of the role of DNA-PK in glycolysis (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001). — DNA-PK regulation of glycolysis contributes to aggressive disease and can be mitigated by co-targeting DNA-PK and glycolysis. A, ALDOA and PKM2 overexpression rescue blunted proliferation by DNA-PK inhibition. B, Co-targeting DNA-PK and glycolysis has additive anti-proliferative effect when using titrating DNA-PKi and 2-DG concentration (0–25 μmol/L). C, Summary schematic of the role of DNA-PK in glycolysis (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001).