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. 2022 Mar 14;28(6):1157–1166. doi: 10.1158/1078-0432.CCR-21-1411

Figure 4.

Figure 4. Immune-related changes by baseline immune status in HNSCC tumor biopsies. A, Patients whose tumors exhibited a low IFNγ signature score at baseline (blue; score < −0.05) had low T-cell and NK-cell function signature scores, consistent with immunologically cold tumors. B, Patients whose tumors showed low IFNγ at baseline responded to SD-101 and demonstrated immunomodulation of relevant gene signature scores and clinical response. All statistical analyses were performed using Prism software v5 (GraphPad Software). A, Correlation was assessed using Pearson correlation coefficient. B, A two-tailed paired t test was done between matched on-treatment (ON Tx) and baseline (PRE) biopsies. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; and ****, P ≤ 0.0001.

Immune-related changes by baseline immune status in HNSCC tumor biopsies. A, Patients whose tumors exhibited a low IFNγ signature score at baseline (blue; score < −0.05) had low T-cell and NK-cell function signature scores, consistent with immunologically cold tumors. B, Patients whose tumors showed low IFNγ at baseline responded to SD-101 and demonstrated immunomodulation of relevant gene signature scores and clinical response. All statistical analyses were performed using Prism software v5 (GraphPad Software). A, Correlation was assessed using Pearson correlation coefficient. B, A two-tailed paired t test was done between matched on-treatment (ON Tx) and baseline (PRE) biopsies. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; and ****, P ≤ 0.0001.