Table 3.

All reported SAEs per patient, viral dose, and relation to treatment.

Patient	Dose (vp)	SAE	Grade	Relation to treatment
5	108	Neck pain (in combination with fever)	2	Unrelated
6	108	Hydrocephalus	4	Unrelated
7	109	Urinary tract infection	2	Unrelated
7	109	Neurological deterioration	3	Unrelated
7	109	Diverticulitis resulting in sigmoid perforation and sepsis	5	Unrelated
9	109	Confusion	4	Related to Delta24-RGD infusion
10	1010	Seizure (generalized)	3	Related to Delta24-RGD infusion
11	1010	Neurological deterioration	2	Unrelated
12	1010	Chronic subdural hematoma	2	Unrelated
13	3 × 1010	Increased intracranial pressure	3	Related to Delta24-RGD infusion
14	Not infused	Neurological deterioration	3	Related to catheter surgery
15	3 × 1010	Meningitis with hydrocephalus	3	Related to Delta24-RGD infusion
16	1010	Wound dehiscence at the site of the Ommaya	3	Related to other study procedure
17	1010	Increased intracranial pressure	3	Related to Delta24-RGD infusion
17	1010	Wound dehiscence at the site of the Ommaya	3	Related to other study procedure
19	1010	Depressed level of consciousness	4	Unrelated
20	1010	Seizure	3	Related to Delta24-RGD infusion