Table 1.

Sunitinib concentrations in tumor tissue, CSF, and plasma.

Patient ID	Treatment duration (days)	Tumor weight (mg)	Tumor tissue (μmol/L)	CSF (μmol/L)	Plasma (μmol/L)
SUN-01	14	16.7	3.0	0.013	0.105
SUN-02	11	7.9	1.5	0.014	0.111
SUN-03	18	16.0	3.4	0.015	0.194
SUN-04 A	13	24.8	1.9	0.023	0.479
SUN-04 B		12.5	1.0
SUN-04 C		18.6	2.2
SUN-05	12	17.0	1.4	NA	0.255
Median	13	16.7	1.9	0.015	0.194

Note: Sunitinib concentrations in micromoles per liter in tumor tissue, CSF, and plasma in 5 patients with GBM after a median of 13 days of preoperative study treatment. SUN-04 A, B, and C are different parts (biological replicates) of the same tumor.