Table 3.

Clinical benefit by gLOH for talazoparib and chemotherapy by line of therapy or breast cancer subtype—ITT population evaluable for clinical benefit and gLOH.

	Talazoparib			Chemotherapy
	gLOH (%) for clinical benefit—yes Median (range), n	gLOH (%) for clinical benefit—no Median (range), n	P value	gLOH (%) for clinical benefit—yes Median (range), n	gLOH (%) for clinical benefit—no Median (range), n	P value
Evaluable ITT	21.3 (0.0–52.7), 100	22.5 (0.0–45.1), 40	0.9762	20.1 (0.3–35.9), 26	20.9 (0.2–40.5), 55	0.4917
No prior lines of chemotherapy	22.0 (0.3–52.7), 44	26.4 (11.0–45.1), 10	0.1022	26.3 (0.3–35.9), 10	19.2 (0.2–40.5), 21	0.5771
1 prior line of chemotherapy	20.4 (0.5–45.2), 33	18.7 (0.0–31.9), 16	0.1872	Not shown (total n < 30)
2 prior lines of chemotherapy	23.1 (0.0–50.3), 21	22.7 (10.9–28.1), 11	0.5406	Not shown (total n < 30)
HR+ BC	18.1 (0.0–50.3), 62	18.91 (6.33–31.9), 15	0.8171	19.1 (1.6–35.9), 21	17.5 (0.2–39.0), 24	0.2633
TNBC	30.8 (0.3–52.7), 37	23.0 (0.0–45.1), 27	0.0456	23.6 (0.3–31.3), 5	26.7 (0.2–40.5), 32	0.3445

Note: Clinical benefit is based on target, nontarget, and new lesions per RECIST 1.1, and confirmation of CR, PR, and SD is not required. Clinical benefit is defined as best overall response of CR, PR, or SD lasting ≥24 weeks from randomization per RECIST 1.1 as determined by investigator. Subgroups shown are subgroups of the evaluable ITT population defined by previous lines of chemotherapy or cancer subtype. P value from two-tailed t test.

Abbreviation: HR⁺ BC, hormone receptor–positive breast cancer.