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. 2022 Mar 14;28(6):1136–1146. doi: 10.1158/1078-0432.CCR-21-3213

Figure 1.

Figure 1. Representative effects of preoperative chemoradiation plus consolidation nivolumab monotherapy. Swimmer's plot of overall survival. From January 2017 to October 2019, a total of 39 patients with microsatellite stable (MSS) locally advanced rectal cancer (LARC) and 5 patients with microsatellite instability-high (MSI-H) LARC were enrolled. Radical surgery was performed for all patients, excluding one patient who declined surgery after achieving a near-complete clinical response with nivolumab. As of December 2020, six patients with MSS LARC experienced recurrence (two local and four distant), and no patients with MSI-H LARC experienced recurrence after a median follow-up of 32.9 and 17.2 months, respectively. One patient with MSS LARC died. The patient who achieved a near-complete clinical response and declined surgery experienced local regrowth and distant metastasis after 18.3 months of follow-up; there was no option for curative resection due to the multiple distant metastases.

Representative effects of preoperative chemoradiation plus consolidation nivolumab monotherapy. Swimmer's plot of overall survival. From January 2017 to October 2019, a total of 39 patients with microsatellite stable (MSS) locally advanced rectal cancer (LARC) and 5 patients with microsatellite instability-high (MSI-H) LARC were enrolled. Radical surgery was performed for all patients, excluding one patient who declined surgery after achieving a near-complete clinical response with nivolumab. As of December 2020, six patients with MSS LARC experienced recurrence (two local and four distant), and no patients with MSI-H LARC experienced recurrence after a median follow-up of 32.9 and 17.2 months, respectively. One patient with MSS LARC died. The patient who achieved a near-complete clinical response and declined surgery experienced local regrowth and distant metastasis after 18.3 months of follow-up; there was no option for curative resection due to the multiple distant metastases.