Table 1.
The list of upstream regulators and their target molecules.
| Upstream regulator (kinase) | Predicted activation state | Target molecules in dataset | P value of overlap |
|---|---|---|---|
| CDK1 | Activated | AURKB, BIRC5, BUB1, BUB1B, CDC20, CDC25A, CDC25C, CDC6, CDT1, FEN1, FOXM1, GAS2L3, H2AX, MCM4, PBK, PLK1, PTTG1, SGO1, STMN1, TTK | 7.63E−10 |
| AURKB | Activated | AURKB, BIRC5, CDCA8, CENPA, DTL, KIF2C, SGO2, SKA1, SKA3, TOP2A | 6.24E−09 |
| PLK1 | Activated | BIRC5, BUB1, BUB1B, CCNB1, CDC20, CDC25C, CEP55, FBXO5, GTSE1, H2AX, HAUS8, KIF2C, KIFC1, PTEN | 2.48E−08 |
| CHEK2 | Activated | BIRC5, CDC25A, CDC25C, CDK1, FOXM1, TTK | 4.84E−05 |
| CHEK1 | Activated | CDC25A, CDC25C, CHEK1, CLSPN, E2F7, E2F8, H2AX | 1.46E−04 |
| TTK | BUB1, BUB1B, KNL1, RMI2 | 1.53E−04 | |
| CDK2 | Activated | CCNA2, CDC25A, CDC6, CDK1, CDT1, CHEK1, KIF11, MCM4, MYBL2, PTTG1 | 5.66E−04 |
| CDKN1A | CDC6, CDK1, CDT1, CHEK1, H2AX | 8.10E−04 | |
| WEE1 | CDK1, H2AX, STMN1 | 0.002 | |
| PRKDC | Activated | CBX5, CHEK1, H2AX, PLK1, TPX2 | 0.002 |
| PLK3 | CDC25C, H2AX, PTEN | 0.003 | |
| MAPK9 | CBX7, CCND3, CDC25A, CDC25C, CHEK1, H2AX | 0.004 | |
| CCNB1 | BIRC5, BUB1, CDC25A, PBK | 0.006 | |
| RPS6KA3 | CHEK1, H2AX, NEK2, SHANK3, STMN1 | 0.009 | |
| BUB1B | BUB1B, CDC20 | 0.013 | |
| RPS6KA2 | CHEK1, FBXO5, NEK2 | 0.016 |