Author response table 1. Result of PS-matching MetS+ and MetS- participants once with BMI inclusion in the PS-matching covariates and once without including BMI.
With BMI in the matching model, MetS+ participants have lower mean KL grades, and without its inclusion, MetS+ participants have higher mean KL grades.
| All OAI subjects | Matched subjects without BMI in matching | Matched subjects with BMI in matching | |||||||
|---|---|---|---|---|---|---|---|---|---|
| MetS– | MetS+ | MetS– | MetS+ | MetS– | MetS+ | ||||
| 7459 | 1810 | SMD | 1803 | 1803 | SMD | N: 1800 | N: 1800 | SMD | |
| Variables included in the PS matching model | |||||||||
| Age (year) [mean (SD)] | 60.38 (9.09) | 64.94 (8.49) | 0.52 | 65.22 (8.95) | 64.90 (8.48) | 0.04 | 65.12 (8.47) | 64.87 (8.46) | 0.03 |
| Sex, Female, N (%) | 4426 (59.3) | 985 (54.4) | 0.10 | 1043 (57.8) | 985 (54.6) | 0.07 | 1014 (56.3) | 983 (54.6) | 0.04 |
| Non-white race [N (%)] | 1468 (19.7) | 494 (27.3) | 0.18 | 439 (24.4) | 487 (27.0) | 0.06 | 481 (26.8) | 488 (27.1) | 0.01 |
| BMI (kg/m2) [mean (SD)] | 28.23 (4.78) | 30.71 (4.43) | 0.54 | 28.09 (4.52) | 30.72 (4.43) | 0.59 | 30.51 (4.53) | 30.69 (4.43) | 0.04 |
| Smoking, current smoker [N (%)] | 517 (6.9) | 120 (6.6) | 0.01 | 113 (6.3) | 120 (6.7) | 0.02 | 107 (5.9) | 120 (6.7) | 0.03 |
| Alcohol use, ≥1/week [N (%)] | 3250 (43.6) | 698 (38.6) | 0.10 | 689 (38.2) | 698 (38.7) | 0.01 | 733 (40.7) | 696 (38.7) | 0.04 |
| PASE score [mean (SD)] | 165.42 (83.48) | 141.00 (76.02) | 0.31 | 137.63 (72.17) | 141.25 (76.03) | 0.05 | 143.72 (78.12) | 141.42 (75.89) | 0.03 |
| Variables not included in the PS matching model | |||||||||
| KL grade, N (%) | 0.21 | 0.12 | 0.11 | ||||||
| Grade 0 | 2875 (38.5) | 540 (29.8) | 634 (35.2) | 538 (29.8) | 511 (28.4) | 539 (29.9) | |||
| Grade 1 | 1318 (17.7) | 345 (19.1) | 317 (17.6) | 342 (19.0) | 283 (15.7) | 342 (19.0) | |||
| Grade 2 | 2019 (27.1) | 515 (28.5) | 496 (27.5) | 514 (28.5) | 549 (30.5) | 511 (28.4) | |||
| Grade 3 | 1005 (13.5) | 332 (18.3) | 296 (16.4) | 331 (18.4) | 375 (20.8) | 331 (18.4) | |||
| Grade 4 | 242 (3.2) | 78 (4.3) | 60 (3.3) | 78 (4.3) | 82 (4.6) | 77 (4.3) | |||
| Medial JSN score, N (%) | 0.22 | 0.17 | 0.04 | ||||||
| Grade 0 | 4625 (65.9) | 937 (55.9) | 1068 (63.4) | 933 (55.8) | 959 (57.1) | 936 (56.0) | |||
| Grade 1 | 1503 (21.4) | 431 (25.7) | 379 (22.5) | 430 (25.7) | 409 (24.4) | 427 (25.6) | |||
| Grade 2 | 742 (10.6) | 255 (15.2) | 205 (12.2) | 254 (15.2) | 265 (15.8) | 254 (15.2) | |||
| Grade 3 | 148 (2.1) | 54 (3.2) | 32 (1.9) | 54 (3.2) | 46 (2.7) | 54 (3.2) | |||
| WOMAC pain score (mean (SD)) | 2.35 (3.28) | 2.96 (3.56) | 0.18 | 2.43 (3.27) | 2.96 (3.56) | 0.16 | 2.75 (3.62) | 2.95 (3.56) | 0.06 |
| Cardio/Cerebrovascular diseases, N (%) | 239 (3.3) | 196 (11.4) | 0.31 | 79 (4.5) | 196 (11.4) | 0.26 | 82 (4.7) | 192 (11.2) | 0.24 |
| Hypertension [N (%)] | 2704 (36.3) | 1734 (95.8) | 1.62 | 750 (41.6) | 1728 (95.8) | 1.44 | 829 (46.1) | 1724 (95.8) | 1.31 |
| Diabetes Mellitus [N (%)] | 86 (1.2) | 646 (36.7) | 1.02 | 18 (1.0) | 641 (36.5) | 1.02 | 13 (0.7) | 636 (36.3) | 1.03 |
| Dyslipidemia [N (%)] | 1010 (13.5) | 1599 (88.3) | 2.26 | 257 (14.3) | 1594 (88.4) | 2.21 | 272 (15.1) | 1591 (88.4) | 2.16 |
| Abdominal obesity [N (%)] | 6293 (84.6) | 1810 (100.0) | 0.60 | 1535 (85.4) | 1803 (100.0) | 0.58 | 1659 (92.6) | 1800 (100.0) | 0.40 |