Table 5.
Excess relative risk and normal tissue complication probabilities for different organs at risk calculated using the TPS data.
| scenario 1 | scenario 2 | scenario 3 | scenario 4 | ||
|---|---|---|---|---|---|
| organ at risk | endpoint | IMRT + brachytherapy | IMRT + SiB | 3D-CRT + brachytherapy | 3D-CRT + sequential boost |
|
left lung
(ipsilateral) |
symptomatic pneumonitis | 1.9 ± 1.0 (1.1 – 4.3) |
2.2 ± 0.7 (1.1 – 3.5) |
1.3 ± 0.3 (0.9 – 1.8) |
1.5 ± 0.7 (0.7 – 3.3) |
|
NTCP
[%] LKB model TPS data |
|
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|
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|
whole lung
NTCP
[%] LKB model TPS data |
radiation pneumonitis (grade ≥ 2) |
1.3 ± 0.7 (0.9 – 3.2) |
1.5 ± 0.6 (1.0 – 3.0) |
1.0 ± 0.2 (0.7 – 1.3) |
1.0 ± 0.3 (0.6 – 1.7) |
|
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|
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|
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|
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| symptomatic pneumonitis | 2.3 ± 1.0 (1.7 – 4.9) |
2.6 ± 0.8 (1.8 – 4.6) |
1.7 ± 0.3 (1.4 – 2.2) |
1.8 ± 0.4 (1.2 – 2.9) |
|
|
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|
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|
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|
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|
heart
ERR [%] Darby model TPS data |
ischemic heart disease | +33.4 ± 9.9 (24.3 – 58.7) |
+32.8 ± 7.2 (20.6 – 44.8) |
+24.5 ± 11.8 (11.4 – 44.6) |
+35.2 ± 15.2 (18.1 – 55.9) |
*marks a pairwise t-test with p ≤ 0.05 including a Welch correction for different variances. **marks a pairwise Mann-Whitney U test with p ≤ 0.05.