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. 2022 Jul 20;14(14):5855–5877. doi: 10.18632/aging.204189

Table 2. GO enrichment analysis of disease mechanisms in SA-AKI.

Ontology ID Description P value FDR
BP 0006954 inflammatory response 4.41E-98 2.71E-94
BP 0042493 response to drug 9.21E-58 2.83E-54
BP 0006955 immune response 2.16E-55 4.43E-52
BP 0045087 innate immune response 1.08E-48 1.66E-45
BP 0032496 response to lipopolysaccharide 2.50E-46 3.08E-43
BP 0001666 response to hypoxia 5.70E-43 5.19E-40
BP 0043066 negative regulation of apoptotic process 5.90E-43 5.19E-40
BP 0008284 positive regulation of cell proliferation 7.95E-41 6.11E-38
BP 0051092 positive regulation of NF-kappaB transcription factor activity 3.14E-39 2.15E-36
BP 0050900 leukocyte migration 1.88E-37 1.16E-34
BP 0071222 cellular response to lipopolysaccharide 4.05E-36 2.26E-33
BP 0045944 positive regulation of transcription from RNA polymerase II promoter 1.28E-35 6.58E-33
BP 0007165 signal transduction 1.86E-34 8.82E-32
BP 0070374 positive regulation of ERK1 and ERK2 cascade 6.05E-33 2.66E-30
BP 0007568 aging 1.46E-32 6.01E-30
BP 0045471 response to ethanol 2.73E-32 1.05E-29
BP 0010628 positive regulation of gene expression 2.58E-30 9.35E-28
BP 0045766 positive regulation of angiogenesis 2.86E-30 9.79E-28
BP 0006915 apoptotic process 1.04E-29 3.36E-27
BP 0050731 positive regulation of peptidyl-tyrosine phosphorylation 3.21E-29 9.89E-27
CC 0005615 extracellular space 3.41E-141 2.46E-138
CC 0005576 extracellular region 1.01E-97 3.64E-95
CC 0070062 extracellular exosome 5.69E-82 1.37E-79
CC 0009986 cell surface 1.58E-54 2.85E-52
CC 0005886 plasma membrane 3.42E-54 4.94E-52
CC 0009897 external side of plasma membrane 1.55E-51 1.87E-49
CC 0005829 cytosol 1.28E-44 1.32E-42
CC 0045121 membrane raft 2.26E-37 2.04E-35
CC 0005925 focal adhesion 4.75E-33 3.82E-31
CC 0005887 integral component of plasma membrane 7.79E-32 5.63E-30
CC 0016020 membrane 1.32E-28 8.68E-27
CC 0072562 blood microparticle 4.56E-26 2.75E-24
CC 0031012 extracellular matrix 4.24E-24 2.36E-22
CC 0031093 platelet alpha granule lumen 8.12E-21 4.20E-19
CC 0043202 lysosomal lumen 2.13E-18 1.03E-16
CC 0043234 protein complex 1.55E-17 6.82E-16
CC 0048471 perinuclear region of cytoplasm 1.60E-17 6.82E-16
CC 0005764 lysosome 2.36E-17 9.47E-16
CC 0005796 Golgi lumen 1.88E-14 7.16E-13
CC 0005911 cell-cell junction 5.39E-13 1.95E-11
MF 0005515 protein binding 7.49E-56 1.32E-52
MF 0005102 receptor binding 1.57E-42 1.38E-39
MF 0019899 enzyme binding 1.75E-31 1.03E-28
MF 0042803 protein homodimerization activity 2.56E-31 1.13E-28
MF 0042802 identical protein binding 7.35E-29 2.59E-26
MF 0005125 cytokine activity 3.02E-27 8.89E-25
MF 0008083 growth factor activity 1.62E-20 4.09E-18
MF 0002020 protease binding 5.13E-20 1.13E-17
MF 0004872 receptor activity 7.69E-19 1.51E-16
MF 0001618 virus receptor activity 2.08E-18 3.67E-16
MF 0019901 protein kinase binding 3.64E-18 5.83E-16
MF 0005088 Ras guanyl-nucleotide exchange factor activity 1.84E-16 2.70E-14
MF 0005179 hormone activity 2.08E-16 2.83E-14
MF 0008201 heparin binding 6.82E-16 8.60E-14
MF 0001948 glycoprotein binding 7.96E-16 9.36E-14
MF 0004252 serine-type endopeptidase activity 3.97E-15 4.38E-13
MF 0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1.00E-14 1.04E-12
MF 0004713 protein tyrosine kinase activity 2.83E-14 2.77E-12
MF 0005164 tumor necrosis factor receptor binding 1.30E-13 1.20E-11
MF 0005178 integrin binding 1.36E-13 1.20E-11