Figure 6.

Multi-region methylation data recapitulates strong PCBrainAge acceleration associations in test data. Conclusions drawn from significant differences in PCBrainAge are graphically outlined by brain region, created with BioRender.com (A). Barplots show the mean PCBrainAge Acceleration as defined by the residual of our mixed linear effects model (eq. 1), with error bars corresponding to a 95% confidence interval. (^*) denotes Benjamini Hochberg corrected p-values < 0.05, where within-region significant comparisons are predominantly highlighted. Acceleration was compared among brain regions between groupings according to clinical diagnosis (B), CERAD scores (C), NIA-Reagan scores (D), Braak Scores (E), and APOE ε4 carrier status (F).