Table 1.
Summary of expression of TRP genes and their isoforms.
| Gene | Isoforms | Differentially expressed (FDR < 0.01) | Expression in α-cells | Expression in β-cells |
|---|---|---|---|---|
| TRPA1 | TRPA1-201, TRPA1-202, TRPA1-203, TRPA1-204, TRPA1-205, TRPA1-206 | ns | nd | nd |
| TRPC1 | TRPC1-201, TRPC1-202, TRPC1-203, TRPC1-204 | In β-cells Gene: 1.5 FC Isoforms: ns |
TRPC1-201, TRPC1-202∗, TRPC1-203, TRPC1-204 | TRPC1-201, TRPC1-202, TRPC1-203, TRPC1-204 |
| TRPC3 | TRPC3-201, TRPC3-202, TRPC3-203, TRPC3-204, TRPC3-205 | ns | nd | nd |
| TRPC4 | TRPC4-201, TRPC4-202, TRPC4-203, TRPC4-204, TRPC4-205, TRPC4-206, TRPC4-207, TRPC4-208, TRPC4-209, TRPC4-210 | In α-cells: Gene: 22.8 FC Isoforms: TRPC4-206 45.0 FC |
TRPC4-206 | TRPC4-206∗ |
| TRPC5 | TRPC5-201 | ns | Low | Low |
| TRPC6 | TRPC6-201, TRPC6-202, TRPC6-203, TRPC6-204, TRPC6-205, TRPC6-206, TRPC6-207 | ns | Low | Low |
| TRPC7 | TRPC7-201, TRPC7-202, TRPC7-203, TRPC7-204, TRPC7-205, TRPC7-206, TRPC7-207 | In α-cells Gene: 7.0 FC Isoforms: ns |
TRPC7-205 | TRPC7-205∗ |
| TRPM1 | TRPM1-201, TRPM1-202, TRPM1-203, TRPM1-204, TRPM1-205, TRPM1-206, TRPM1-207, TRPM1-208, TRPM1-209, TRPM1-210, TRPM1-211, TRPM1-212 | ns | nd | nd |
| TRPM2 | TRPM2-201, TRPM2-202, TRPM2-203, TRPM2-204, TRPM2-205, TRPM2-206, TRPM2-207, TRPM2-208 | ns | Low | Low |
| TRPM3 | TRPM3-201, TRPM3-202, TRPM3-203, TRPM3-204, TRPM3-205, TRPM3-206, TRPM3-207, TRPM3-208, TRPM3-209, TRPM3-210, TRPM3-211, TRPM3-212, TRPM3-213, TRPM3-214, TRPM3-215, TRPM3-216 | In β-cells Gene: 25.0 FC Isoforms: TRPM3-201 23.3 FC; TRPM3-202 200.0 FC; TRPM3-205 20.0 FC; TRPM3-207 14.5 FC; TRPM3-209 20.8 FC; TRPM3-212 16.6 FC |
TRPM3-201∗, TRPM3-202∗, TRPM3-205∗, TRPM3-206∗, TRPM3-207∗, TRPM3-209∗, TRPM3-212∗ | TRPM3-201, TRPM3-202, TRPM3-205, TRPM3-206, TRPM3-207, TRPM3-209, TRPM3-212 |
| TRPM4 | TRPM4-201, TRPM4-202, TRPM4-203, TRPM4-204, TRPM4-205, TRPM4-206, TRPM4-207, TRPM4-208, TRPM4-209, TRPM4-210, TRPM4-211, TRPM4-212, TRPM4-213, TRPM4-214 | ns | TRPM4-203, TRPM4-204, TRPM4-205, TRPM4-208, TRPM4-213, TRPM4-214 | TRPM4-203, TRPM4-204, TRPM4-205, TRPM4-208, TRPM4-213, TRPM4-214 |
| TRPM5 | TRPM5-201, TRPM5-202, TRPM5-203, TRPM5-204 | ns | Low | Low |
| TRPM6 | TRPM6-201, TRPM6-202, TRPM6-203, TRPM6-204, TRPM6-205 | ns | Low | Low |
| TRPM7 | TRPM7-201, TRPM7-202, TRPM7-203, TRPM7-204, TRPM7-205, TRPM7-206, TRPM7-207, TRPM7-208, TRPM7-209, TRPM7-210 | ns | TRPM7-202, TRPM7-203, TRPM7-204, TRPM7-205, TRPM7-206, TRPM7-210 | TRPM7-202, TRPM7-203, TRPM7-204, TRPM7-205, TRPM7-206, TRPM7-210 |
| TRPM8 | TRPM8-201, TRPM8-202, TRPM8-203, TRPM8-204, TRPM8-205, TRPM8-206, TRPM8-207, TRPM8-208, TRPM8-209, TRPM8-210, TRPM8-211, TRPM8-212, TRPM8-213, TRPM8-214 | ns | nd | nd |
| TRPV1 | TRPV1-201, TRPV1-202, TRPV1-203, TRPV1-204, TRPV1-205, TRPV1-206, TRPV1-207, TRPV1-208, TRPV1-209, TRPV1-210 | ns | TRPV1-203, TRPV1-205, TRPV1-207 | TRPV1-203, TRPV1-205, TRPV1-207 |
| TRPV2 | TRPV2-201, TRPV2-202, TRPV2-203, TRPV2-204, TRPV2-205, TRPV2-206, TRPV2-207, TRPV2-208, TRPV2-209 | ns | TRPV2-209 | TRPV2-209 |
| TRPV3 | TRPV3-201, TRPV3-202 TRPV3-203, TRPV3-204, TRPV3-205, TRPV3-206, TRPV3-207, TRPV3-208, TRPV3-209, TRPV3-210, TRPV3-211 |
ns | TRPV3-202, TRPV3-208 | TRPV3-202, TRPV3-208 |
| TRPV4 | TRPV4-201, TRPV4-202, TRPV4-203, TRPV4-204, TRPV4-205, TRPV4-206, TRPV4-207, TRPV4-208 | ns | Low | Low |
| TRPV5 | TRPV5-201, TRPV5-202, TRPV5-203 | ns | nd | nd |
| TRPV6 | TRPV6-201, TRPV6-202, TRPV6-203, TRPV6-204, TRPV6-205, TRPV6-206, TRPV6-207, TRPV6-208, TRPV6-209 | ns | Low | Low |
| TRPML1 | TRPML1-201, TRPML1-202, TRPML1-203, TRPML1-204, TRPML1-205, TRPML1-206, TRPML1-207, TRPML1-208, TRPML1-209, TRPML1-210 | In β-cells Gene: 1.8 FC Isoforms: TRPML1-204 3.7 FC |
TRPML1-201, TRPML1-202, TRPML1-203, TRPML1-204, TRPML1-205, TRPML1-208, TRPML1-210 | TRPML1-201, TRPML1-202, TRPML1-203, TRPML1-204, TRPML1-205, TRPML1-208, TRPML1-210 |
| TRPML2 | TRPML2-201, TRPML2-202, TRPML2-203, TRPML2-204, TRPML2-205, TRPML2-206 | ns | nd | nd |
| TRPML3 | TRPML3-201, TRPML3-202, TRPML3-203, TRPML3-204, TRPML3-205, TRPML3-206 | ns | TRPML3-201, TRPML3-202, TRPML3-203, TRPML3-204, TRPML3-205, TRPML3-206 | TRPML3-201, TRPML3-202, TRPML3-203, TRPML3-204, TRPML3-205, TRPML3-206 |
| PKD2 | PKD2-201, PKD2-202, PKD2-203, PKD2-204, PKD2-205, PKD2-206, PKD2-207 | ns | PKD2-201, PKD2-203, PKD-205, PKD2-206, PKD2-207 | PKD2-201, PKD2-203, PKD-205, PKD2-206, PKD2-207 |
| PKD2L1 | PKD2L1-201, PKD2L1-202, PKD2L1-203, PKD2L1-204 | ns | nd | nd |
| PKD2L2 | PKD2L2-201, PKD2L2-202, PKD2L2-203, PKD2L2-204, PKD2L2-205, PKD2L2-206, PKD2L2-207 | ns | Low | Low |
Legend: ns: not significant; FC: fold-change; nd: not detected (mean TPM < 0.5); ∗mostly absent in this cell population.