Extended Data Table 1.

Linear Mixed-Effects Models (LME)

Table shows the results of linear-mixed models applied to the major findings in Figs. 1 and 2. Experiment, relevant Figure, number of mice recorded, number of cells recorded, and number of cells recorded per mouse (cells/mouse) are indicated alongside measures of activity, namely the mean z-scored change of activity for all recorded cells (Effect) and mean z-scored change of activity for all recorded cells in each mouse (Effect/mouse(z)). Statistical measurements of activity variance attributable to activity differences across mice (ICC, or Intra-class correlations), as well as p-values obtained using a permutation test (p(permtest)) or a linear mixed-effects model taking into account activity variance across mice (p(lme)) are also shown. Intra-class correlations were calculated using the equation varbetween mice/vartotal . Note that permutation tests used 10,000 permutations, making 1e-4 the lowest possible p-value obtainable by those tests. Time window indicates the phase of ingestion during which activity was quantified. The “oral” time window was defined as the 30 s immediately following the start of the first licking bout. The “GI” time window was defined as the 12 min immediately following the onset of IG infusion. The “Systemic” time window was defined as the time over which the infused, or injected solution would be absorbed into the blood (0–20 min after the end of IG infusion or self-paced consumption, 0–30 min after intraperitoneal injection).