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. 2022 Jul 27;608(7922):381–389. doi: 10.1038/s41586-022-05014-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Schematic of the optogenetic silencing design, as in Fig. 1g. b, Average optogenetic silencing effect on responses to cues (FAs), probes (FAs), and targets (hits) for all areas silenced (labels), during both tasks (Discrimination, blue, and WM, red), and for the two silencing onsets (at the onset of the delay, left, and at the onset of the stimulus, right). Individual bars represent the differences in mean FA or miss rate between silenced and control trials (n = 173,432, pooled from all 9 mice). Error bars represent 95% CI of silencing trials. Shaded background regions group the areas silenced into contralateral, ipsilateral, and visual cortical areas. c, Statistical significance of optogenetic silencing effects (p values) for each effect shown in b, two-sided Fisher’s exact test, with statistically significant effects in bold font. Significance thresholds were adjusted for multiple comparisons (36 comparisons, Bonferroni correction, α = 0.0014).