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. 2022 Aug 10;608(7922):360–367. doi: 10.1038/s41586-022-05023-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 13 — a, Somatic WGS CNV profile of patient 1 diagnosed with medulloblastoma (grade IV, desmoplastic/nodular, SHH-activated) with b, match normal blood. c, Somatic WGS CNV profile of Chr 2, 3 and 9 of patient 2 diagnosed with medulloblastoma (grade IV, classic morphology, SHH-activated) with d, match normal blood. Notably inferCNV analysis on Visium data did not show any genomic variability in chr 2 but since Visium and WGS data were generated from different locations of each tumour, we speculate that the observed WGS CNV patterns in patient 2 could be due to the inherent spatial heterogeneity of DNA copy number alterations observed by others when sampling multiple sites of medulloblastoma tumours. e, Somatic WGS CNV profile of Chr 2, 3 and 9 of patient 3 diagnosed with CNS embryonal tumour (grade IV, multi-layered rosettes, NOS) with d, match normal blood. No CNV was detected by WGS in the chromosomes not displayed. WGS = Whole-genome sequencing. Chr = Chromosome. SHH = Sonic hedgehog. CNS = Central nervous system. NOS = Not otherwise specified.